Discovery of novel 2-(alkylmorpholin-4-yl)-6-(3-fluoropyridin-4-yl)-pyrimidin-4(3H)-ones as orally-active GSK-3β inhibitors for Alzheimer’s disease was written by Fukunaga, Kenji;Sakai, Daiki;Watanabe, Kazutoshi;Nakayama, Kazuki;Kohara, Toshiyuki;Tanaka, Hiroshi;Sunada, Shinji;Nabeno, Mika;Okamoto, Masako;Saito, Ken-Ichi;Eguchi, Jun-ichi;Mori, Akiko;Tanaka, Shinji;Inazawa, Keiko;Horikawa, Takashi. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2015.Product Details of 5856-63-3 This article mentions the following:
The authors herein describe the results of further evolution of GSK-3β inhibitors for Alzheimer’s disease from the promising compounds with in vivo tau phosphorylation inhibitory activity by oral administration. Introduction of a low alkyl group instead of the Ph group at the 3-position of the morpholine moiety aiming to improve pharmacokinetic profiles resulted in potent low mol. weight GSK-3β inhibitors with good in vitro pharmacokinetic profiles, which also showed in vivo tau phosphorylation inhibitory activity by oral administration. Effect of the stereochem. of the alkyl moiety is also discussed using docking models. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Product Details of 5856-63-3).
(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Product Details of 5856-63-3
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts