Biodegradable and stimuli sensitive amphiphilic graft copolymers and their sol-gel phase transition behavior was written by Tamer, Yasemin;Yildirim, Hueseyin. And the article was included in Polymers for Advanced Technologies in 2015.Application of 4074-88-8 This article mentions the following:
PH and temperature-sensitive biodegradable poly(β-aminoester)-graft-poly(ε-caprolactone)-block-methoxy poly(ethylene glycol) (PBAE-g-PCL-b-mPEG) amphiphilic graft copolymers with different mol. weights were synthesized. The structure of these copolymers was adjusted by varying the feed ratios of ε-caprolactone to methoxy poly(ethylene glycol)s (mPEG), amine and diacrylate monomer amounts and the mol. weight of mPEG. Aqueous solutions of these copolymers formed micelles at lower concentrations; however, the concentrated solutions showed a reversible sol-gel transition property depending on both pH and temperature changes under representative physiol. conditions (pH 7.4, 37°C). The effects of the mol. weight of pH-sensitive poly(β-aminoester) block and mPEG group, the hydrophobic to hydrophilic block ratio (PCL/mPEG) and the concentration of the copolymer on the sol-gel transition were investigated. Proton NMR (1H NMR) and gel permeation chromatog. measurements were used to characterize the structure of the synthesized copolymers. The self-assemble behavior and critical micelle concentration of the amphiphilic copolymers were estimated in phosphate buffer solution using fluorescence spectroscopy. The gelling behavior was measured by using tube inversion method. At pH 7.4, all copolymer solutions prepared 20 wt% concentration indicated sol-gel transition with increasing temperature In vitro degradation experiments displayed that the synthesized graft copolymers mostly degraded hydrolytically within 20 days under physiol. conditions. In order to investigate the potential application of synthesized hydrogels in drug delivery, Methylene Blue was used and approx. 70% of the loaded amount was released in 120 h. The findings indicate that obtained graft copolymers can be used as injectable biodegradable carriers for pharmaceutical drugs. Copyright © 2015 John Wiley & Sons, Ltd. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Application of 4074-88-8).
Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Application of 4074-88-8
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts