Efficient Synthesis of (R)-2-Chloro-1-(2,4-dichlorophenyl)ethanol with a Ketoreductase from Scheffersomyces stipitis CBS 6045 was written by Shang, Yue-Peng;Chen, Qi;Kong, Xu-Dong;Zhang, Yu-Jun;Xu, Jian-He;Yu, Hui-Lei. And the article was included in Advanced Synthesis & Catalysis in 2017.Recommanded Product: (R)-1-(3-Chlorophenyl)ethanol This article mentions the following:
By enzyme screening, a ketoreductase cloned from Scheffersomyces stipitis CBS 6045 and named SsCR was identified that could catalyze the asym. hydrogenation of a variety of aromatic ketones. SsCR exhibited a specific activity of 65 U mg-1 protein and excellent enantioselectivity (99.9% ee) towards the hydrophobic substrate 2-chloro-1-(2,4-dichlorophenyl)ethanone, which is an intermediate in the synthesis of common antifungal agents such as miconazole, econazole and sertaconazole. The kinetic parameter kcat/Km was 4.51×103 s-1 mM-1, showing the great catalytic efficiency of SsCR towards this substrate. Mol. dynamic simulation results shed light on the higher substrate binding free energy change for this substrate relative to other substrates. Based on the good catalytic properties of SsCR, (R)-2-chloro-1-(2,4-dichlorophenyl)ethanol could be obtained with a space-time yield (STY) of up to 268 g L-1 d-1 without any addnl. cofactor required in the reductive reaction process. On scaling up the bioreaction, the (R)-alc. was isolated with 88.2% yield and 99.9% ee. The environmental factor (E factor) of this reaction was 7.25 when process water was excluded. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Recommanded Product: (R)-1-(3-Chlorophenyl)ethanol).
(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: (R)-1-(3-Chlorophenyl)ethanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts