A novel o-nitrobenzyl-based photocleavable antitumor prodrug with the capability of releasing 5-fluorourail was written by Mo, Shuli;Wen, Ying;Xue, Fengfeng;Lan, Haichuang;Mao, Yueyuan;Lv, Guanglei;Yi, Tao. And the article was included in Science Bulletin in 2016.Name: 3-(Hydroxymethyl)-4-nitrophenol This article mentions the following:
An o-nitrobenzyl-based photocleavable antitumor prodrug with a terminal carboxyl group was designed and synthesized. The photolysis properties of the prodrug were investigated by means of 1H NMR, HPLC, UV, and MTT methods. The results showed that the toxicity of the anticancer drug was effectively shielded before release. However, the prodrug effectively regained the antitumor capability against cancer cells by release of 5-fluorouracil when it was exposed to UV irradiation In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Name: 3-(Hydroxymethyl)-4-nitrophenol).
3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Name: 3-(Hydroxymethyl)-4-nitrophenol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts