Site-Selective Acylation of Phenols Mediated by a Thioacid Surrogate through Sodium Thiosulfate Catalysis was written by Liao, Wei-Jr;Lin, Sih-Yu;Kuo, Yu-Shan;Liang, Chien-Fu. And the article was included in Organic Letters in 2022.Name: (4-Chlorophenyl)methanol This article mentions the following:
Sodium thiosulfate was used as the sulfur source that reacts with anhydrides to generate acyl-Bunte salts, after which a reaction with phenols was induced. This protocol can be applied for the site-selective acylation of the phenolic hydroxyl group in the presence of other alc. groups. The advantages of this acylation method are operational simplicity, high efficiency, and the use of odorless reagents with low toxicity. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Name: (4-Chlorophenyl)methanol).
(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Name: (4-Chlorophenyl)methanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts