Discovery of a novel and potent series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases was written by Claridge, Stephen;Raeppel, Franck;Granger, Marie-Claude;Bernstein, Naomy;Saavedra, Oscar;Zhan, Lijie;Llewellyn, David;Wahhab, Amal;Deziel, Robert;Rahil, Jubrail;Beaulieu, Normand;Nguyen, Hannah;Dupont, Isabelle;Barsalou, Annie;Beaulieu, Carole;Chute, Ian;Gravel, Serge;Robert, Marie-France;Lefebvre, Sylvain;Dubay, Marja;Pascal, Roussen;Gillespie, Jeff;Jin, Zhiyun;Wang, James;Besterman, Jeffrey M.;MacLeod, A. Robert;Vaisburg, Arkadii. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Application In Synthesis of Thieno[3,2-b]pyridin-7-ol This article mentions the following:
A series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases is described. The compounds demonstrated potency with IC50 values in the low nanomolar range in vitro while the lead compound also showed in vivo activity against various human tumor xenograft models in mice. Further exploration of this class of compounds is underway. In the experiment, the researchers used many compounds, for example, Thieno[3,2-b]pyridin-7-ol (cas: 107818-20-2Application In Synthesis of Thieno[3,2-b]pyridin-7-ol).
Thieno[3,2-b]pyridin-7-ol (cas: 107818-20-2) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Application In Synthesis of Thieno[3,2-b]pyridin-7-ol
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