Month: December 2022

Fernandes, Tiago A. published the artcileMild homogeneous oxidation and hydrocarboxylation of cycloalkanes catalyzed by novel dicopper(II) aminoalcohol-driven cores, Related Products of alcohols-buliding-blocks, the publication is Journal of Molecular Catalysis A: Chemical (2017), 426(Part_B), 357-367, database is CAplus.

N-benzylethanolamine (Hbea) and triisopropanolamine (H₃tipa) were applied as unexplored aminoalc. N,O-building blocks for the self-assembly generation of two novel dicopper(II) compounds, [Cu₂(μ-bea)₂(Hbea)₂](NO₃)₂ (1) and [Cu₂(H₃tipa)₂(μ-pma)]·7H₂O (2) {H₄pma = pyromellitic acid}. These were isolated as stable and aqua-soluble microcrystalline products and were fully characterized by IR spectroscopy, ESI-MS(±), and single-crystal X-ray diffraction, the latter revealing distinct Cu₂ cores containing the five-coordinate copper(II) centers with the {CuN₂O₃} or {CuNO₄} environments. Compounds 1 and 2 were used as homogeneous catalysts for the mild oxidation of C5-C8 cycloalkanes to give the corresponding cyclic alcs. and ketones in up to 23% overall yields based on cycloalkane. The reactions proceed in aqueous acetonitrile medium at 50 °C using H₂O₂ as an oxidant. The effects of different reaction conditions were studied, including the type and loading of catalyst, amount and kind of acid promoter, and water concentration Despite the fact that different acids (HNO₃, H₂SO₄, HCl, or CF₃COOH) promote the oxidation of alkanes, the reaction is exceptionally fast in the presence of a catalytic amount of HCl, resulting in the TOF values of up to 430 h^-1. Although water typically strongly inhibits alkane oxidations due to the reduction of H₂O₂ concentration and lowering of the alkane solubility, in the systems comprising 1 and 2 we observed a significant growth (up to 5-fold) of an initial reaction rate in the cyclohexane oxidation on increasing the amount of H₂O in the reaction mixture The bond-, regio- and stereo-selectivity parameters were investigated in oxidation of different linear, branched, and cyclic alkane substrates. Both compounds 1 and 2 also catalyze the hydrocarboxylation of C5-C8 cycloalkanes, by CO, K₂S₂O₈, and H₂O in a water/acetonitrile medium at 60 °C, to give the corresponding cycloalkanecarboxylic acids in up to 38% yields based on cycloalkanes.

Journal of Molecular Catalysis A: Chemical published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lopes, Ana Claudia Alencar published the artcileProduction and characterization of a new distilled beverage from green coffee seed residue, Computed Properties of 106-25-2, the publication is Food Chemistry (2022), 131960, database is CAplus and MEDLINE.

This study evaluated green coffee seed residue (GCSR) as an alternative substrate for producing distilled beverages. Two proportions of GCSR, 10% and 20% (w/v), were fermented and distilled in a copper alembic still. The spirits were characterized by GC-FID, HS-SPME GC-MS, and sensory anal. by trained panelists. Most of the 62 identified volatile compounds were affected by the GCSR concentration Total terpenes, higher alcs., and acetals showed the highest concentrations in the 10% GCSR spirit. Esters, acetates, and aldehydes were most abundant in the 20% GCSR. In the sensory anal., the 10% GCSR spirit was characterized by floral, dairy, and almond aromas, while the 20% GCSR spirit was embodied coffee, vegetable, hazelnut, cooked cabbage, and nut descriptors. The results demonstrate the potential of GCSR as a substrate for producing coffee spirits with chem. and sensory qualities, with the 10% GCSR being the better option for fermentation

Food Chemistry published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Computed Properties of 106-25-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rudke, Adenilson Renato published the artcileA comparative study of phenolic compounds profile and in vitro antioxidant activity from buriti (Mauritia flexuosa) by-products extracts, Synthetic Route of 90-64-2, the publication is LWT–Food Science and Technology (2021), 111941, database is CAplus.

In general, buriti seeds (BSE) and buriti shells (BSH) are discarded or used as animal feed. However, these materials may have other destinations. Therefore, the aim of this work was to obtain extracts from BSE and BSH using different extraction techniques and solvents in order to evaluate their effects on phenolic profile and antioxidant capacity of the recovered extracts Global yield, total phenolic content (TPC), in vitro antioxidant activities, and phenolic composition accessed by LC-ESI-MS/MS were evaluated. Principal component anal. (PCA) was used as a tool to correlate the observed data. Raw material, solvent type, and extraction method influenced the obtained results mainly in relation to the phenolic composition BSH showed higher values of global yield, antioxidant activity, and TPC, compared to BSE. Considering the 46 phenolic compounds analyzed, 28 were quantified from BSE and 33 from BSH samples. Protocatechuic acid was the major phenolic compound found in most samples, except for the BSH extract obtained with pressurized liquid extraction (PLE), which presented quercetin as the main phenolic compound PCA anal. demonstrated that flavonoids are most associated with the BSH, while phenolic acids and phenolic aldehydes are most related to BSE samples.

LWT–Food Science and Technology published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Synthetic Route of 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mao, Di published the artcileA Synthetic Hybrid Molecule for the Selective Removal of Human Pluripotent Stem Cells from Cell Mixtures, Recommanded Product: 3-(Methylamino)phenol, the publication is Angewandte Chemie, International Edition (2017), 56(7), 1765-1770, database is CAplus and MEDLINE.

A major hurdle in stem cell therapy is the tumorigenic risk of residual undifferentiated stem cells. This report describes the design and evaluation of synthetic hybrid mols. that efficiently reduce the number of human induced pluripotent stem cells (hiPSCs) in cell mixtures The design takes advantage of Kyoto probe 1 (KP-1), a fluorescent chem. probe for hiPSCs, and clin. used anticancer drugs. Among the KP-1-drug conjugates we synthesized, we found an exceptionally selective, chem. tractable mol. that induced the death of hiPSCs. Mechanistic anal. suggested that the high selectivity originates from the synergistic combination of transporter-mediated efflux and the cytotoxicity mode of action. The present study offers a chem. and mechanistic rationale for designing selective, safe, and simple reagents for the preparation of non-tumorigenic clin. samples.

Angewandte Chemie, International Edition published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C7H9NO, Recommanded Product: 3-(Methylamino)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Serratore, Nicholas A. published the artcileIntegrating Metal-Catalyzed C-H and C-O Functionalization To Achieve Sterically Controlled Regioselectivity in Arene Acylation, HPLC of Formula: 328-90-5, the publication is Journal of the American Chemical Society (2018), 140(31), 10025-10033, database is CAplus and MEDLINE.

One major goal of organometallic chemists is the direct functionalization of the bonds most recurrent in organic mols.: C-H, C-C, C-O, and C-N. An even grander challenge is C-C bond formation when both precursors are of this category. Parallel to this is the synthetic goal of achieving reaction selectivity that contrasts with conventional methods. Electrophilic aromatic substitution (EAS) via Friedel-Crafts acylation is the most renowned method for the synthesis of aryl ketones, a common structural motif of many pharmaceuticals, agrochems., fragrances, dyes, and other commodity chems. However, an EAS synthetic strategy is only effective if the desired site for acylation is in accordance with the electronic-controlled regioselectivity of the reaction. Herein we report steric-controlled regioselective arene acylation with salicylate esters via iridium catalysis to access distinctly substituted benzophenones. Exptl. and computational data indicate a unique reaction mechanism that integrates C-O activation and C-H activation with a single iridium catalyst without an exogenous oxidant or base. We disclose an extensive exploration of the synthetic scope of both the arene and the ester components, culminating in the concise synthesis of the potent anticancer agent hydroxyphenstatin.

Journal of the American Chemical Society published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C18H15N3O3, HPLC of Formula: 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kesavan, Arunachalam published the artcileCatalytic enantioselective oxysulfenylation of o-vinylanilides, Safety of 2-Phenylethanethiol, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(2), 282-285, database is CAplus and MEDLINE.

Tf₂NH-Assisted BINAM-derived thiophosphoramide catalysis was accomplished for the enantioselective oxysulfenylation of o-vinylanilides with N-(aryl/alkylthio)imides. The developed reaction offered access to diverse substituted aryl/alkylthio tethered 3,1-benzoxazines I [R = 6-MeO, 6-Cl, 7-Cl, 8-MeO, 8-BzO; R¹ = Ph, 4-EtC₆H₄, 4-FC₆H₄, etc.; Ar = Ph, Bn, 2-MeC₆H₄, etc.; Ar¹ = Ph, 4-MeC₆H₄, 3-IC₆H₄, etc.] in excellent yields and enantiomeric ratios. Furthermore, synthetic applications of benzoxazines and aryl/alkylthio moieties and a transition state model for the observed enantioselectivity were also discussed.

Chemical Communications (Cambridge, United Kingdom) published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Safety of 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts