Fast microwave-promoted palladium-catalyzed synthesis of phthalides from bromobenzyl alcohols utilizing DMF and Mo(CO)6 as carbon monoxide sources was written by Wu, Xiongyu;Mahalingam, A. K.;Wan, Yiqian;Alterman, Mathias. And the article was included in Tetrahedron Letters in 2004.Recommanded Product: 60666-70-8 This article mentions the following:
A fast method utilizing in situ generated CO for the synthesis of phthalides was developed. DMF and Mo(CO)6 were applied as two alternative CO-sources in these microwave promoted carbonylation-lactone formation reactions. Mo(CO)6 was found to be the more generally applicable CO-source and provided phthalides as well as dihydroisocoumarin, 1-isoindolinone, and phthalimide from the corresponding aryl bromide via an efficient CO insertion within a 1 h reaction time. In the experiment, the researchers used many compounds, for example, (2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8Recommanded Product: 60666-70-8).
(2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: 60666-70-8
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts