Improving Stability of Vitamin B5 Through Double Salt Formation was written by Liang, Xuan;Zhang, Qi;Zhang, Zaiyong;Ding, Qiaoce;Mei, Xuefeng. And the article was included in Crystal Growth & Design in 2021.Reference of 137-08-6 This article mentions the following:
Calcium pantothenate (CP) is a chem. unstable vitamin and sensitive to moisture, heat, acid, and alkali. The poor physicochem. properties have greatly limited its biol. performance and applications. In this work, four new double salts of CP with pantoic acid calcium salt (PA), calcium isobutyrate (IBA), calcium β-hydroxy-β-Me butyrate (HMB), and calcium lactate (LA) were synthesized aiming to reduce the moisture sensitivity and to enhance the stability. The three double salts (CP-PA, CP-IBA, CP-HMB) were fully characterized by single crystal X-ray diffraction, powder X-ray diffraction, differential scanning calorimetry, thermogravimetric anal., and dynamic vapor sorption. In addition, their hygroscopicity and chem. stability under different conditions were also studied. The results show that all four double salts present improved hygroscopicity, phys. stability, and chem. stability. Notably, compared to CP pure forms, CP-PA and CP-LA present significantly lower moisture absorption and obviously improved stability. This work provides a new method to improve the hygroscopicity, phys. stability, and chem. stability of organic salts. In the experiment, the researchers used many compounds, for example, Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6Reference of 137-08-6).
Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Reference of 137-08-6
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts