Synthesis of proline analogues as potent and selective cathepsin S inhibitors was written by Kim, Mira;Jeon, Jiyoung;Song, Jiyeon;Suh, Kwee Hyun;Kim, Young Hoon;Min, Kyung Hoon;Lee, Kwang-Ok. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2013.Name: (R)-2-Aminobutan-1-ol This article mentions the following:
Cathepsin S is a potential target of autoimmune disease. A series of proline-derived compounds were synthesized and evaluated as cathepsin S inhibitors. We discovered potent cathepsin S inhibitors through structure-activity relationship studies of proline analogs. In particular, compound 19-(S) showed promising in vitro/vivo pharmacol. activities and properties as a selective cathepsin S inhibitor. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Name: (R)-2-Aminobutan-1-ol).
(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Name: (R)-2-Aminobutan-1-ol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts