Zhou, Xiao-yan published the artcileEffectiveness and safety of carboprost tromethamine in prevention and treatment of bleeding during cesarean section in high-risk parturients, Quality Control of 58551-69-2, the publication is Zhongguo Fuyou Baojian (2017), 32(22), 5539-5541, database is CAplus.
Objective: The article explored the effectiveness and safety of preventive intrauterine injection of carboprost tromethamine in the prevention and treatment of bleeding during cesarean section in high-risk parturients. Methods: The article selected 381 women with high-risk factors for postpartum hemorrhage during cesarean section admitted to the obstetrics department of Sichuan Provincial Maternity and Child Health Hospital from Jan. 2015 to Dec. 2016 as the research objects. They were divided according to the uterine body injection of uterine contraction drugs. 3 groups, each with 127 cases. Women in the control group were given 20 IU of oxytocin plus 500mL of compound sodium chloride i.v. infusion immediately after the fetus was delivered; study group 1 was given 20 IU of oxytocin plus 500mL of compound sodium chloride i.v. infusion immediately after the fetus was delivered 250 μg carprost tromethamine was injected into the uterus; study group 2 immediately after the fetus was delivered, 250 μg carprost tromethamine was injected into the uterus. The article compares the clin. treatment effect, operation time, intraoperative and postoperative blood loss, incidence of postpartum hemorrhage, hemostasis of postpartum hemorrhage and adverse reactions among the three groups of women. Results: The total effective rate of the control group was significantly lower than that of study group 1 and study group 2, and the difference was statistically significant (P < 0.05); the total effective rate of study group 1 and study group 2 was compared, and the difference was not statistically significant (P > 0.05). There was no statistically significant difference in the operation time between the three groups of women (P > 0.05). In the control group, the amount of bleeding and the incidence of postpartum hemorrhage during operation, 2h, 24h after operation were significantly higher than that of study group 1 and study group 2, and the differences were statistically significant (all P < 0.05); study group 1 during operation and 2h after operation Compared with study group 2, the amount of bleeding and the incidence of postpartum hemorrhage at 24h were not statistically significant (P > 0.05). The use of therapeutic uterine contractions in study group 1 and study group 2 was significantly less than that of control group, and the differences were statistically significant (P < 0.05). A total of 29 cases of adverse reactions occurred in all parturients, with an incidence of 22.83%. The incidence of adverse reactions in the control group, study group 1, and study group 2 were 3.94%, 11.18%, and 7.09%, resp. Conclusion: Carprost tromethamine was effective in preventing and treating high-risk parturientsâ?bleeding during cesarean section, and it was worthy of clin. application.
Zhongguo Fuyou Baojian published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C10H15ClO3S, Quality Control of 58551-69-2.
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