Zhao, Hongyi published the artcileEfficient and stereoselective one-pot synthesis of benzo[b]oxazolo[3,4-d][1,4]oxazin-1-ones, Recommanded Product: 4,5-Difluoro-2-nitrophenol, the publication is RSC Advances (2020), 10(40), 24037-24044, database is CAplus and MEDLINE.
An efficient and mild one-pot convergent synthesis protocol has been developed for benzo[b]oxazolo[3,4-d][1,4]oxazin-1-one derivatives through the Mitsunobu reaction and sequential cyclization. Various tricyclic fused benzoxazinyl-oxazolidinones (20 examples) were obtained in good to excellent yields and high enantioselectivities with facile operation. Furthermore, four stereoisomers were afforded resp. in high ee values (>97.8%) via using different chiral 2,3-epoxy-4-trityloxybutanol. This methodol. has been applied to the synthesis of key intermediates of drug candidates.
RSC Advances published new progress about 55346-97-9. 55346-97-9 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Nitro Compound,Benzene,Phenol, name is 4,5-Difluoro-2-nitrophenol, and the molecular formula is C24H29N5O3, Recommanded Product: 4,5-Difluoro-2-nitrophenol.
Referemce:
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