Zhang, Da-wei published the artcileUltrasonic-assisted synthesis of 1,4-disubstituted 1,2,3-triazoles via various terminal acetylenes and azide and their quorum sensing inhibition, Product Details of C10H8ClNO2, the publication is Ultrasonics Sonochemistry (2017), 343-353, database is CAplus and MEDLINE.
An efficient synthesis of 1,4-disubstituted 1,2,3-triazole derivatives I (R = C6H5, 2-ClC6H4, 3-O2NC6H4, etc.) and II was studied. 1,4-Disubstituted 1,2,3-triazoles containing isoxazole and thymidine structures were synthesized in 84-96% yields starting from various terminal isoxazole ether alkynes and β-thymidine azide derivatives via a 1,3-dipolar cycloaddition using copper acetate, sodium ascorbate as the catalyst under ultrasonic assisted condition. Furthermore, the quorum sensing inhibitory activities of synthesized compounds were evaluated with Chromobacterium violaceum (C. Violaceum CV026) based on their inhibition of violacein production, with compound C10-HSL as a pos. control. The compounds II (R = C6H5, 4-ClC6H4,and 4-C(CH3)3C6H4) exhibited considerable levels of inhibitory activity against violacein production, and IC50 values were 217 +/- 19, 223 +/- 20 and 42.8 +/- 4.5 μM, resp., which highlighted the potential of these compounds as lead structures for further research towards the development of novel QS inhibitors.
Ultrasonics Sonochemistry published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C12H17NS2, Product Details of C10H8ClNO2.
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