Yin, Yue published the artcileClinical analysis of Hemabate combined with oxytocin for prevention of postpartum hemorrhage after cesarean section in high-risk parturients, Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Xiandai Zhenduan Yu Zhiliao (2017), 28(8), 1407-1408, database is CAplus.
To observe the prevention and safety effect and safety of Hemabate combined with oxytocin on postpartum hemorrhage of cesarean women with high risk factors of postpartum hemorrhage. The 240 pregnant women undergoing cesarean section with high risk factors of postpartum hemorrhage, such as uterine weakness, placenta previa, twin pregnancy, giant fetus, polyhydramnios, scarred uterus, etc., were selected as the research subjects, and they were randomly divided into observation group and 120 cases in each control group. In the control group, oxytocin 20U was injected i.v. after the fetus was delivered to prevent postpartum hemorrhage, and the observation group was combined with the control group with 250 μg deep i.m. injection of Hemabate. We observed and compared the bleeding volume and the incidence of postpartum hemorrhage and adverse reactions during cesarean section, 2h postpartum and 24h postpartum between the two groups. In the observation group, the average blood loss at 2h and 24h after delivery was significantly lower than that in the control group (P < 0.05). The incidence of postpartum hemorrhage in the observation group was 1.67% significantly lower than 11.67% in the control group (P < 0.05). There were 16 cases of postpartum adverse reactions in the observation group, the symptoms were mild and alleviated spontaneously. For pregnant women undergoing cesarean section with high risk factors for postpartum hemorrhage. The preventive use of Hemabate significantly reduces the amount of intraoperative and postpartum hemorrhage, reduces the incidence of postpartum hemorrhage, and the medication is safe, convenient and effective.
Xiandai Zhenduan Yu Zhiliao published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C10H10CoF6P, Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.
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