Yan, Cui-hua published the artcileEfficacy and safety of carboprost tromethamine combined with low B-Lynch suture in treatment of refractory placenta previa postpartum hemorrhage, Computed Properties of 58551-69-2, the publication is Zhongguo Linchuang Yanjiu (2016), 29(4), 541-543, database is CAplus.
Objective: To explore the clin. efficacy and safety of carboprost tromethamine combined with low B-Lynch suture in the treatment of refractory placenta previa and postpartum hemorrhage (PPH). Methods: Using retrospective research methods, 108 patients with refractory placental previa PPH admitted from May 2011 to May 2015 were divided into control group (n=53) and observation group (n=55) according to the treatment method. . Both groups were given cesarean section for delivery. The control group was given oxytocin, and the placenta was dissected with 8 intermittent suture. The observation group was treated with carboprost tromethamine combined with low B-Lynch suture. The clin. efficacy, intraoperative blood loss, vaginal bleeding 2h postoperatively, vaginal bleeding 24h postoperatively, and the incidence of adverse reactions were compared between the two groups. If the hemostasis is ineffective, the two groups of patients will be treated with catheter arterial embolization (TAE) to stop the bleeding. If the TAE fails to stop the bleeding, hysterectomy will be performed. Results: (1) After treatment, the number of markedly effective, effective and ineffective cases in the observation group were 34, 19 and 2 resp., and the total clin. effective rate was 96.36% (53/55), the number of markedly effective, effective and ineffective cases in the control group were resp. 15 cases, 24 cases and 14 cases, and the total clin. effective rate was 73.58% (39/53). The difference in efficacy between the two groups was statistically significant (P<0.05). (2) There was no statistically significant difference in intraoperative blood loss between the two groups (P>0.05), but the vaginal bleeding in the observation group was significantly less than that in the control group at 2h and 24h after surgery (P<0.01). (3) The incidence of adverse reactions after treatment in the control group was 22.64% (12/53), and the observation group was 7.27% (4/55). The difference in the incidence of adverse reactions between the two groups was statistically significant (P<0.01). Conclusion: Carboprost tromethamine combined with low B-Lynch suture in the treatment of refractory placenta previa postpartum hemorrhage has a significant clin. effect and a low incidence of postoperative adverse reactions.
Zhongguo Linchuang Yanjiu published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C37H30ClIrOP2, Computed Properties of 58551-69-2.
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