Wang, Zhi-mei published the artcileEffect of carboprost tromethamine on amount of bleeding in cesarean section at different time points of high risk parturients, Application of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Zhongguo Yaofang (2014), 25(4), 336-338, database is CAplus.
The aim of this paper is to observe the effects of carboprost tromethamine on the amount of bleeding in cesarean section of high risk parturients at different time points. The clin. data of 180 high risk parturients with postpartum hemorrhage tendency in cesarean section were retrospectively analyzed and divided into treatment group and control group according to the duration of carboprost tromethamine treatment. Treatment group was given intrauterine injection of carboprost tromethamine 250 μg and i.v. dripping of oxytocin 10 u after the delivery of fetus; control group was given intrauterine injection of carboprost tromethamine 250 μg if the amount of bleeding increased because uterine inertia and uterine massage was invalid, following intrauterine injection of oxytocin 10 u i.v. after the delivery of fetus. Both groups were given carboprost tromethamine continuously, depending on the situation. The amounts of bleeding and adverse drug reactions were recorded in 2 groups. The incidence of postpartum hemorrhage in treatment group was 17.7%, which was significantly lower than in control group(28.7%); the amounts of bleeding in treatment group 2 h and 24 h after operation were significantly lower than in control group; there was statistical significance(P<0.05). Adverse drug reaction of 2 groups was slight and recovered spontaneously. The application of carboprost tromethamine in advance could effectively decrease postpartum hemorrhage in high risk parturients with postpartum hemorrhage tendency, and it’s safety.
Zhongguo Yaofang published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C9H8O4, Application of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.
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