Wang, Yu-Huang published the artcileReductive hydroxyalkylation/alkylation of amines with lactones/esters, COA of Formula: C8H19NO, the publication is Organic & Biomolecular Chemistry (2012), 10(32), 6504-6511, database is CAplus and MEDLINE.
We have developed a one-pot method for the direct intermol. reductive hydroxyalkylation or alkylation of amines using lactones or esters as the hydroxyalkylating/alkylating reagents. The method is based on the in situ amidation of lactones/esters with DIBAL-H-amine complex (for primary amines) or DIBAL-H-amine hydrochloride salt complex (for secondary amines), followed by reduction of the amides with an excess of DIBAL-H. Different from the reduction of Weinreb amides with DIBAL-H where aldehydes are formed, the reduction of the in situ formed Weinreb amides yielded amines. Moreover, this method is not limited to Weinreb amides, instead, it also works for other amides in general. A plausible mechanism is suggested to account for the outcome of the reactions.
Organic & Biomolecular Chemistry published new progress about 4543-95-7. 4543-95-7 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 4-(Butylamino)butan-1-ol, and the molecular formula is C6H5F4NO3S, COA of Formula: C8H19NO.
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