Wang, Yinli published the artcileEnhanced Molecular Recognition through Substrate-Additive Complex Formation in N-Heterocyclic-Carbene-Catalyzed Kinetic Resolution of α-Hydroxythioamides, COA of Formula: C8H8O3, the publication is ACS Catalysis (2022), 12(10), 6100-6107, database is CAplus.
A new way of understanding enhanced mol. recognition through substrate-additive complex formation and the development of the first catalytic kinetic resolution of α-hydroxythioamides RCH(OH)C(S)NH(R1) (R = Me, cyclopropyl, Ph, etc.; R1 = Et, t-Bu, 3,5-bis(trifluoromethyl)phenyl, etc.), which are versatile synthetic building blocks, using chiral N-heterocyclic carbene I-catalyzed enantioselective acylation assisted by a carboxylate additive viz., 9-Julolidinecarboxylic acid was described. Mass spectrometry provided evidence for the role of the additive, which forms a hydrogen-bonded complex with α-hydroxythioamide, resulting in both rate and selectivity enhancements. The synthetic applications of the resolved α-hydroxythioamides highlight the usefulness of the developed method.
ACS Catalysis published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C7H9NO, COA of Formula: C8H8O3.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts