Wang, Xiaoliang published the artcileDetermination of sucrose and sorbitol in ambroxol hydrochloride oral solution by HPLC-RID, Category: alcohols-buliding-blocks, the publication is Jinri Yaoxue (2021), 31(10), 756-760, database is CAplus.
OBJECTIVE To establish a method for determination of sucrose and sorbitol in ambroxol hydrochloride oral solution and investigated the addition among samples from 21 manufacturers all over the whole country. METHODS The HPLC determination was performed on a HYPERSIL amino column (250 mm×4.6 mm, 5 μm). The mobile phase was consisted of acetonitrile and water (80:20, V/V) at the flow rate of 1.0 mL·min-1. The column temperature was 35°C and the refractive index detector was used. RESULTS Sucrose and sorbitol could be well separated from ambroxol hydrochloride, and they had good linear relationship (n=6) at the range of 1-10 mg·mL-1 with sucrose (r=0.9996) and sorbitol (r=0.9999), resp. The limits of quantitation of sucrose and sorbitol were 8.03 and 8.04 μg resp. and the average recoveries (n=9) were 101.0% and 100.9% with the RSD 1.03% and 0.97% resp. The samples from 22 enterprises in the whole country were determined and the determinated results for few individual manufacturers were inconsistent with the production prescription. CONCLUSION The established method is simple, accurate and good repeatability which can lay the foundation for the determination of the addition and quality evaluation of flavor agents in oral solution
Jinri Yaoxue published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C6H10O7, Category: alcohols-buliding-blocks.
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