Qiu, Qian published the artcileEffect of ergometrine combined with carboprost tromethamine on preventing postpartum hemorrhage in patients with scar uterus after cesarean section and its effect on GSH-Px SOD MDA and postpartum lactation, Category: alcohols-buliding-blocks, the publication is Hebei Yixue (2021), 27(11), 1901-1907, database is CAplus.
Objective: To investigate the effect of the combination of Ergometrine and Carboprost Tromethamine Injection in preventing postpartum hemorrhage in patients with scarred uterus re-cesarean section and its influence on glutathione peroxidase (GSH-px), superoxide dismutase (SOD), malondialdehyde (MDA) and postpartum lactation. Methods: A total of 92 patients with scarred uterus re-cesarean section in our hospital from Feb. 2018 to Apr. 2020 were selected as the research objects. They were divided into observation group and control group by simple randomization method, with 46 cases in each group. The control group was treated with Carboprost Tromethamine Injection to prevent postpartum hemorrhage, and the observation group was treated with Ergometrine combined with Carboprost Tromethamine Injection to prevent postpartum hemorrhage. The efficacy, postpartum hemorrhage, recovery, lactation, and adverse reactions, coagulation function indexes [activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen (FIB), D-dimer (DD)], serum GSH-px, SOD, MDA levels before and 24 h after the operation of the two groups were compared. Results: After treatment, the total effective rate of the observation group was 93.48% higher than that of the control group 76.09% (P<0.05). The bleeding volume and rate of postpartum hemorrhage at 2 h and 24 h in the observation group were lower than those in the control group, the duration of lochia and hospital stay were shorter than those in the control group, and the uterine fundus declined faster than the control group (P<0.05). The levels of APTT, PT, FIB, DD, and serum MDA in the two groups aT24 h after surgery were lower than those before the operation, and the observation group was lower than the control group, and the serum GSH-px and SOD levels were higher than those before operation, and the observation group was higher than the control group (P<0.05). The lactation initiation time of the observation group was shorter than that of the control group, and the lactation volume scores of the 1 and 2 d postpartum were higher than those of the control group (P<0.05); there was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: The combined application of Ergometrine and Carboprost Tromethamine Injection to prevent postpartum hemorrhage in patients with scarred uterus re-cesarean section can significantly improve the preventive effect, reduce postpartum hemorrhage, and promote the recovery of patients, improve coagulation function and lactation, reduce serum GSH-px, SOD, MDA levels, reduce oxidative stress, and have good safety.
Hebei Yixue published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Category: alcohols-buliding-blocks.
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