Pilkington-Miksa, Michael A. published the artcileTargeting lipopolyplexes using bifunctional peptides incorporating hydrophobic spacer amino acids: Synthesis, transfection, and biophysical studies, Related Products of alcohols-buliding-blocks, the publication is Bioconjugate Chemistry (2007), 18(6), 1800-1810, database is CAplus and MEDLINE.
We have developed efficient synthetic routes to two hydrophobic amino acids, suitably protected for solid-phase peptide synthesis, and have successfully synthesized peptides containing these or other hydrophobic amino acids as spacers between a Lys16 moiety and an integrin-targeting motif. These peptides have in turn been used to formulate a range of lipopolyplex vectors with Lipofectin and plasmid DNA. The transfection efficiencies of these vectors and their aggregation behavior in buffers and in serum have been studied. We have shown that vectors containing peptides incorporating long linkers that are entirely hydrophobic are less efficient transfection agents. However, linkers of equivalent length that are in part hydrophobic show improved transfection properties, which is probably due to the improved accessibility of the integrin-binding motif.
Bioconjugate Chemistry published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Related Products of alcohols-buliding-blocks.
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https://en.wikipedia.org/wiki/Alcohol,
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