Nie, AiHua published the artcileDrug discovery based on the structure of FKBP12: Design, synthesis and evaluation of L-1,4-thiazane-3-carboxylic acid derivatives as neuroimmunophilin ligands, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Science in China, Series B: Chemistry (2007), 50(3), 405-417, database is CAplus.
By choosing neuroimmunophilin FKBP12 as a therapeutical target, the authors have attempted to discover a new structural drug for treating neurodegenerative disease. This drug should possess neurotrophic activity and not affect the immune system. Based on the crystal structure of FKBP12, FK506 and Calcineurin complex, small organic mols. were designed. These mols. were to have the ability of binding to FKBP12 in a virtual screening. By using a solution parallel synthetic method, these compounds were synthesized. The neuroprotective and neuroregenerative activities of these compounds were evaluated by binding assays, PC12 cells survival and neurite outgrowth model, chick dorsal root ganglion cultures (DRG) and 6-OHDA lesioned mice sympathetic nerve endings model. The evaluation results of these compounds showed that (2S)-2-[[[(3R)-4-(4-toluenesulfonyl)thiomorpholin-3-yl]carbonyl]amino]-4-methylpentanoic acid Et ester (N308) has great promise as a candidate for a neuroprotective and neuroregenerative agent.
Science in China, Series B: Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts