Lin, Xing-zhe published the artcileAnalysis on clinical effects and safeties of carboprost tromethamine of different administration modes in treatment of postpartum hemorrhage, Synthetic Route of 58551-69-2, the publication is Zhongguo Fuyou Baojian (2016), 31(22), 4660-4662, database is CAplus.
Objective To evaluate the clin. effects of i.m. and cervical injection of carboprost tromethamine in treatment of postpartum hemorrhage. Methods A total of 460 patients were randomly divided into control group (318 cases) and exptl. group (142 cases). The cases in control group were treated by i.m. injection of carboprost tromethamine (250 μg), while the cases in exptl. group were treated by cervical injection of carboprost tromethamine (250 μg). The amounts of endometrorrhagia and colporrhagia within 2 h after the end of the third stage of labor and the incidence rates of adverse reactions in the two groups were compared. Results The amounts of endometrorrhagia in exptl. group and control group were (71.43±13.96) ml and (50.56±10.78) ml, resp. (P<0.05); the amounts of colporrhagia in exptl. group and control group were (35.31±6.32) ml and (44.27±8.31) ml, resp. (P<0.05); the incidence rates of adverse reactions in exptl. group and control group were 16.12% and 11.66%, resp. (P>0.05). Conclusion It is recommended to treat uterine inertia patients by i.m. injection to prevent and treat postpartum hemorrhage; cervical injection should be selected to prevent postpartum hemorrhage among the patients with other causes.
Zhongguo Fuyou Baojian published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Synthetic Route of 58551-69-2.
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