Li, Li published the artcileClinical effect of oxytocin combined with prostaglandins on prevention of postpartum hemorrhage of high-risk pregnancy puerpera with caesarean section, Synthetic Route of 58551-69-2, the publication is Xiandai Yaowu Yu Linchuang (2014), 29(6), 619-622, database is CAplus.
The aim of this paper is to investigate the clin. efficacy of oxytocin combined with prostaglandins in the prevention of postpartum hemorrhage of high-risk pregnancy puerpera with caesarean section. High-risk pregnancy puerpera(330 cases) with caesarean section in Affiliated Hospital of Yan’an University from Jan. 2012 to Dec. 2013 were randomly divided into 3 groups(110 cases in each group): carboprost tromethamine+oxytocin(CTO) group, carboprost methylate+oxytocin(CMO) group, and oxytocin group. And patients in the CTO group were i.m. given carboprost tromethamine 250 μg in the body of uterus following fetus expulsion, and then were iv oxytocin 10 U. The patients in the CMO group were sublingual administered with carboprost methylate 1 mg following fetus expulsion, and were iv oxytocin 10 U. The patients in the oxytocin group were iv oxytocin 10 U following fetus expulsion, and were i.m. given oxytocin 10 U in body of uterus. The quantity of bleeding was compared among the three groups during the operation, 2, and 2-4 h after operation. The postpartum hemorrhage, blood transfusion, and addnl. hemostatic measures after delivery were observed among the three groups. The side reaction was also observed among the three groups. During operation, 2, and 2-4 h after operation, the quantity of bleeding of maternal in the CTO group was less than that in the CMO group and oxytocin group, with the significant difference(P<0.05). During the operation, 2 h after operation, the quantity of bleeding of maternal in the CMO group was significantly less than that in the oxytocin group(P<0.05). While 2-4 h after the operation, there was no significant difference. The postpartum hemorrhage, blood transfusion rate, and addnl. intervention measures to stop bleeding in the CTO and CMO groups were significantly lower than those in the oxytocin group(P<0.05). The side effects of the three groups were 9.09%, 8.18%, and 6.36%, resp., and there was no significant difference. CTO is effective in preventing postpartum hemorrhage of high-risk pregnancy. CMO could reach a certain preventive effect, but the application of oxytocin simply showed poor efficacy.
Xiandai Yaowu Yu Linchuang published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Synthetic Route of 58551-69-2.
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