Guo, Yinghua published the artcileImaging of lysosomal oxidative stress during autophagy with a ratiometric probe featuring a large probe-product spectral separation, Recommanded Product: 2-Morpholinoethanol, the publication is Sensors and Actuators, B: Chemical (2021), 129713, database is CAplus.
Autophagy is a physiol. process governing proteostasis and implicated in many diseases. Enhanced ROS levels was known to be associated with lysosomal autophagy and therefore a lyso-specific ROS probe could find applications in autophagy related studies. Following the probe-design principle of bridging-group modification, we previously developed a ROS probe capable of detect a broader range of reactive species than the existing probes. Addnl. merits of the probe include ratiometry-capability, minimal probe-product spectral crosstalk, resistance toward autoxidation at lysosomal acidity, and structural simplicity. It is the aim of this manuscript to render this probe lyso-specificity and examine its potentials to monitor autophagy-related ROS generation in HeLa cells treated by H2O2 or 6-OHDA.
Sensors and Actuators, B: Chemical published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Recommanded Product: 2-Morpholinoethanol.
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