Guo, Gao-feng published the artcileOxycodone inhibits adverse reactions of carboprost tromethamine and influence of inflammatory cytokines during cesarean section, COA of Formula: C25H47NO8, the publication is Guangdong Yixue (2017), 38(20), 3197-3199, 3203, database is CAplus.
Objective: The paper observed the effect of oxycodone on the adverse reactions of carprost tromethamine during cesarean section and its effect on inflammatory cytokines. Methods: Fifty parturients undergoing cesarean section with elective spinal anesthesia, aged 25-35 years old, ASA grade I or II, were divided into oxycodone group (group A) and control group (B) by random number table method group). Group A was given oxycodone 0.07 mg/kg after carboprost tromethamine was given to the parturients, and group B was given symptomatic treatment after carboprost tromethamine adverse reactions occurred in the parturients. The two groups of parturients applied the same formula for postoperative analgesia, and both groups were diluted with normal saline. The paper observed the adverse reactions after the administration of carprost tromethamine and observed the changes in heart rate (HR), mean arterial pressure (MAP), and pulse oxygen saturation (SpO2) at 2, 5, and 10 min, and observed the changes before and after the administration of oxycodone. Maternal peripheral blood interleukin-2 (IL-2) and VAS scores at relevant time points after surgery were performed at 6, 12, 24, and 48 h after surgery. Results: Comparing group A and group B, the adverse reactions of carboprost tromethamine were significantly reduced, the level of IL-2 in peripheral venous blood was significantly increased at 6, 12, 24, and 48 h after surgery (P < 0.05), VAS score Significantly reduced (P < 0.05). Compared with group B, there were no statistically significant differences in MAP, HR, and SpO2 at 2 and 10 min after carboprost tromethamine (P > 0.05); but 5 min after carprost tromethamine was administered when compared with group B, MAP and HR were significantly reduced, the difference was statistically significant (P < 0.05), and the SpO2 difference was not statistically significant (P > 0.05). Conclusion: Oxycodone 0.07 mg/kg applied in cesarean section could significantly reduce the adverse reactions of carprost tromethamine, provide good postoperative analgesia, and increase the secretion of IL-2 after cesarean section. The vital signs of women who were given proper oxycodone during cesarean section were more stable.
Guangdong Yixue published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, COA of Formula: C25H47NO8.
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