Ebner, A. published the artcileFunctionalization of AFM Tips and supports for molecular recognition force spectroscopy and recognition imaging, Related Products of alcohols-buliding-blocks, the publication is Methods in Molecular Biology (New York, NY, United States) (2019), 117-151, database is CAplus and MEDLINE.
Linking of sensor mols. (e.g., antibodies) to an AFM tip converts it into a biosensor by which single target mols. (e.g., antigens) can be detected and localized on the sample surface. Moreover, the mechanism of interaction can be studied by force spectroscopy if purified target mols. are linked to an ultra-flat surface, such as mica or silicon (nitride). Rapid imaging of the binding sites and force spectroscopy studies are greatly facilitated if 6-10 nm long polyethylene glycol (PEG) chains are used as flexible tethers between the sensor mol. and the tip. Here, we describe a set of methods by which a variety of proteins, oligonucleotides, or small mols. can be tethered to silicon (nitride) tips or to mica. Methods are included which afford site-specific and oriented coupling of the sensor mols.
Methods in Molecular Biology (New York, NY, United States) published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Related Products of alcohols-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts