Dong, Li published the artcileStudy on the application timing of tromethamine in cesarean section of patients with central placenta previa, Computed Properties of 58551-69-2, the publication is Zhongguo Fuyou Baojian (2016), 31(18), 3701-3703, database is CAplus.
Objective To explore the application timing of tromethamine in cesarean section of patients with central placenta previa. Methods Sixty-four women underwent cesarean section in Department of Obstetrics and Gynecol. in the hospital from Jan. 2013 to Dec. 2014, then they were diagnosed as central placenta previa and divided into observation group and control group based on random number table according to the sequence of admission, 32 women in each group. The patients in observation group were treated by tromethamine immediately after delivery of fetus, while the patients in control group were treated by tromethamine after delivery of placenta. The numbers of automatic placental expulsion, the numbers of manual removal of placenta, operation time, and the amounts of blood loss during operation in the two groups were compared. Results The amounts of blood loss during operation and at two hours after operation in observation group were statistically significantly less than those in control group (P<0.01). There was no statistically significant difference in the amount of blood loss within 24 h after operation between the two groups (P>0.05). The rate of automatic placental expulsion in observation group was statistically significantly higher than that in control group, while the rate of manual removal of placenta in observation group was statistically significantly lower than that in control group (P<0.01). The operation time in observation group was statistically significantly shorter than that in control group (P<0.01). Six patients in observation group were treated by uterine gauze, while fourteen patients in control group were treated by uterine gauze, there was statistically significant difference between the two groups (P<0.01). The rates of intraoperative and postoperative blood transfusion in observation group and control group were 15.6% and 37.5%, resp., there was statistically significant difference between the two groups (P<0.01). There was no statistically significant difference in the incidence rate of adverse reactions between the two groups (P>0.05). Conclusion Uterine body injection of tromethamine immediately after delivery of fetus during cesarean section of patients with central placenta previa can quickly promote lower segment uterine contraction, improve placental delivery rate, reduce the amount of blood loss during operation, shorten operation time, the adverse reactions are few, but the price is expensive, so it can be used as obstetric emergency medication or preventive medication of high risk pregnant women.
Zhongguo Fuyou Baojian published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Computed Properties of 58551-69-2.
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