Computers & Chemical Engineering published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Related Products of alcohols-buliding-blocks.
Cui, Lei published the artcileData-driven prediction of the product formation in industrial 2-keto-L-gulonic acid fermentation, Related Products of alcohols-buliding-blocks, the publication is Computers & Chemical Engineering (2012), 386-391, database is CAplus.
Mixed culture fermentation of Bacillus megaterium and Gluconobacter oxydans is widely used to produce 2-keto-L-gulonic acid (2-KGA), a key precursor for L-ascorbic acid synthesis. For such mixed cultivation, kinetic modeling is difficult because the interactions between the two strains are not well known yet. In this paper, data-driven prediction of the product formation is presented for the purpose of better process monitoring. A rolling learning-prediction approach based on neural networks is practiced to predict 2-KGA formation. Techniques associated with the approach, such as the data pretreatment and the rolling learning-prediction mechanism, are given in more detail. The validation results by using the data from com. scale 2-KGA cultivation indicate that the prediction error is less than 5% in the later phase of fermentation and the reliable prediction time span is 8 h. The robustness of the prediction approach is further tested by adding extra noises to the process variables.
Computers & Chemical Engineering published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Related Products of alcohols-buliding-blocks.
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