Chen, Weiqi published the artcileSubstrate stereocontrol in bromine-induced intermolecular cyclization: asymmetric synthesis of pitavastatin calcium, Name: (R)-Oxiran-2-ylmethanol, the publication is Tetrahedron (2015), 71(29), 4730-4737, database is CAplus.
A novel approach to synthesize pitavastatin calcium, an effective HMG-CoA reductase inhibitor, based on readily available and attractively functionalized (R)-3-chloro-1,2-propanediol is reported. This work highlights an intermol. diastereoselective bromine-induced cyclization of homoallylic carbonate to meet stereochem. challenges in the synthesis of statins. An efficient route to a new triphenylphosphonium tetrafluoroborate salt of a quinoline core is also presented.
Tetrahedron published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Name: (R)-Oxiran-2-ylmethanol.
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