Xu, Pingxi published the artcileDEET and other repellents are inhibitors of mosquito odorant receptors for oviposition attractants, SDS of cas: 42822-86-6, the main research area is Culex Aedes Anopheles DEET odorant receptor oviposition attractant; CquiOR2; CquiOR21; CquiOR37; CquiOR99; Inhibitor; Outward current.
In addition to its primary function as an insect repellent, DEET has many “”off-label”” properties, including a deterrent effect on the attraction of gravid female mosquitoes. DEET neg. affects oviposition sites. While deorphanizing odorant receptors (ORs) using the Xenopus oocyte recording system, we have previously observed that DEET generated outward (inhibitory) currents on ORs sensitive to oviposition attractants. Here, we systematically investigated these inhibitory currents. We recorded dose-dependent outward currents elicited by DEET and other repellents on ORs from Culex quinquefasciatus, Aedes aegypti, and Anopheles gambiae. Similar responses were observed with other plant-derived and plant-inspired compounds, including Me jasmonate and Me dihydrojasmolate. Inward (regular) currents elicited by skatole upon activation of CquiOR21 were modulated when this oviposition attractant was coapplied with a repellent. Compounds that generate outward currents in ORs sensitive to oviposition attractants elicited inward currents in a DEET-sensitive receptor, CquiOR136. The best ligand for this receptor, Me dihydrojasmolate, showed repellency activity but was not as strong as DEET in our test protocol.
Insect Biochemistry and Molecular Biology published new progress about Aedes aegypti. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, SDS of cas: 42822-86-6.
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