Sudhakar, Sekar published the artcileBiodistribution and pharmacokinetics of thiolated chitosan nanoparticles for oral delivery of insulin in vivo, Application In Synthesis of 7575-23-7, the main research area is thiolated chitosan nanoparticle insulin oral delivery pharmacokinetics; Bioavailability; Chitosan; Insulin; Mucoadhesion; Oral delivery.
To improve the quality of life of diabetic patients, oral delivery of insulin would be better than s.c. injection, and the encapsulation of insulin for its oral delivery is a promising alternative one. In this study, we prepared an oral insulin delivery system using thiolated chitosan nanoparticles (TCNPs) loaded with insulin (Ins) and tested under in vitro and in vivo systems. TCNPs prepared from CS and pentaerythritol tetrakis (3-mercaptopropionate) (PETMP) at 4:1 ratio showed 220 ± 4 nm, 2.3 ± 1 mV, and 119 ± 4μmol g-1 in their size, charge and sulfhydryl content, resp . There was a sustained release of insulin from the TCNPs at pH 5.3. TCNPs treatment did not alter cell viability in vitro and oral administration of TCNPs reached over the tip of the microvilli near the intestinal mucosa in vivo. There were increased and decreased the levels of insulin and glucose in the blood, resp. when Ins-TCNPs were orally administered in the diabetes induced rats. Thus, our results suggested that the insulin stays significantly for a prolonged period to make bio-distribution and bioavailability due to its interaction with the mucus of the intestine, thus offering a better oral insulin delivery system for diabetic patients.
International Journal of Biological Macromolecules published new progress about Bioavailability. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Application In Synthesis of 7575-23-7.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts