Sharma, Mahima published the artcileBacopa monnieri attenuates glutamate-induced nociception and brain mitochondrial toxicity in Zebrafish, COA of Formula: C4H6O5, the main research area is Bacopa Danio glutamate nociception brain mitochondrial toxicity apoptosis; Apoptosis; Bacopa monnieri; Brain; Glutamate; Mitochondria; Zebrafish.
Bacopa monnieri L.(BM; Family: Scrophulariaceae), commonly known as Brahmi, is traditionally used as a nootropic agent. BM also exhibits significant analgesic activity in exptl. models of pain. However, the effect of Bacopa monnieri against glutamate-induced nociception in zebrafish is yet to be explored in exptl. condition. Therefore, the present study was designed to evaluate the effect of BM against glutamate-induced nociception and brain mitochondrial toxicity in adult zebrafish (Danio rerio). BM at 0.625, 1.25 and 2.5 mg/mL was administered to adult zebrafish and after half an hour glutamate was injected through i.m. route of administration. Indomethacin was used as standard drug. After behavioral anal., the fish were euthanized and the brain was isolated and stored for further biochem. anal. BM (1.25 and 2.5 mg/mL) and indomethacin significantly attenuated the glutamate-induced increase in number of line crossing compared to control group animals. Addnl., BM (1.25 and 2.5 mg/mL) and indomethacin significantly reduced the glutamate induced increase in cytosolic calcium level. Further, there was a substantial improvement in mitochondrial function, integrity and bioenergetics in term of respiratory control rate and ADP/O in zebrafish brain. Moreover, BM (1.25 and 2.5 mg/mL) and indomethacin significantly reduced the glutamate-induced mitochondria-dependent apoptosis in zebrafish brain. Therefore, BM could be a potential alternative drug candidate in the management of pain.
Metabolic Brain Disease published new progress about Acute toxicity. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, COA of Formula: C4H6O5.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts