Schauber, Juergen published the artcileHuman rectal mucosal gene expression after consumption of digestible and non-digestible carbohydrates, Recommanded Product: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is rectum mucosa gene expression profile nutrition sucrose isomalt.
The effects of regular consumption of the low-digestible and prebiotic carbohydrate isomalt (Palatinit) vs. the digestible sucrose on gene expression in the rectal mucosa were examined in 19 healthy humans. They received 30 g isomalt or sucrose daily as part of controlled diet over two 4-wk test periods with a 4-wk washout in between. At the end of each test phase, rectal biopsies were obtained. After RNA extraction, mucosal gene expression was assayed using GeneChip microarrays. The expression of cathelicidin hCap18/LL37, cellular detoxification enzymes GSTπ, UGT1A1 and CYP3A4, cyclooxygenase 2, and barrier factors MUC2 and ZO-1 were determined by real-time RT-PCR. Microbiol. analyses of fecal samples revealed a shift of the gut flora to increased bifidobacteria counts following consumption of isomalt. Isomalt did not affect the rectal mucosal gene expression in microarray analyses compared to sucrose. The expression of cathelicidin LL37, GSTπ, UGT1A1, CYP3A4, COX-2, MUC2 and ZO-1 was not changed in rectal biopsies. Thus, gene expression of the human rectal mucosa can be reliably measured in biopsy samples taken at endoscopy. Dietary intervention with the low-digestible isomalt compared to sucrose did not affect the gene expression in the rectal mucosa.
Molecular Nutrition & Food Research published new progress about Bifidobacterium. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Recommanded Product: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts