Qaisar, Rizwan published the artcileRestoration of sarcoplasmic reticulum Ca2+ ATPase (SERCA) activity prevents age-related muscle atrophy and weakness in mice, Computed Properties of 97-67-6, the main research area is muscle atrophy weakness SERCA gastrocnemius CDN1163 sarcopenia MEF2C; sarcopenia; sarcoplasmic reticulum calcium-transporting ATPase; skeletal muscle.
Sarcopenia has a significant neg. impact on healthspan in the elderly and effective pharmacol. interventions remain elusive. We have previously demonstrated that sarcopenia is associated with reduced activity of the sarcoplasmic reticulum Ca2+ ATPase (SERCA) pump. We asked whether restoring SERCA activity using pharmacol. activation in aging mice could mitigate the sarcopenia phenotype. We treated 16-mo male C57BL/6J mice with vehicle or CDN1163, an allosteric SERCA activator, for 10 mo. At 26 mo, maximal SERCA activity was reduced 41% in gastrocnemius muscle in vehicle-treated mice but maintained in old CDN1163 treated mice. Reductions in gastrocnemius mass (9%) and in vitro specific force generation in extensor digitorum longus muscle (11%) in 26 vs. 16-mo-old wild-type mice were also reversed by CDN1163. CDN1163 administered by intra-peritoneal injection also prevented the increase in mitochondrial ROS production in gastrocnemius muscles of aged mice. Transcriptomic anal. revealed that these effects are at least in part mediated by enhanced cellular energetics by activation of PGC1-α, UCP1, HSF1, and APMK and increased regenerative capacity by suppression of MEF2C and p38 MAPK signaling. Together, these exciting findings are the first to support that pharmacol. targeting of SERCA can be an effective therapy to counter age-related muscle dysfunction.
International Journal of Molecular Sciences published new progress about Aging, animal. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Computed Properties of 97-67-6.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts