Pinheiro, Fernanda C. published the artcileDispersive liquid-liquid microextraction of Cd, Hg and Pb from medicines prior to ICP OES determination according to the United States Pharmacopeia, Application In Synthesis of 111-87-5, the main research area is cadmium mercury lead tablet dispersive liquid microextraction ICPOES.
A simple, sensitive and matrix-effect free anal. method for simultaneous determination of Cd, Hg and Pb in drug samples (i.e., com. dosage tablets) by inductively coupled plasma optical emission spectrometry (ICP OES) has been developed. According to the USP (USP) Chapter 232, those metals are considered elemental impurities from class 1 and they must be assessed in pharmaceutical production as well as in quality control evaluation. In order to increase the sensitivity of the anal., dispersive liquid-liquid microextraction (DLLME) was performed and seven factors affecting analyte extraction were optimized by multivariate anal. A microvolume of analyte enriched phase was directly introduced into the plasma using a multi-nebulizer, providing a high enrichment factor. When compared to conventional ICP OES anal., DLLME improves the limit of quantitation (LOQ) values on average 40-fold for all analytes. Consequently, LOQ values were significantly lower than their permissible daily exposure limits for oral drugs. Accuracy was evaluated by addition and recovery experiments following USP recommendations in eight com. drug samples. Recovery and RSD values were within the range of 90-108% and 1-9%, resp.
Analytical Methods published new progress about Centrifugation. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Application In Synthesis of 111-87-5.
Referemce:
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Alcohols – Chemistry LibreTexts