Nishimura, Mitsugu published the artcileEfficient GC/MS analysis of hydroxy lipid compounds from geochemical samples using tertiary-butyldimethylsilyl etherification, Application In Synthesis of 13099-34-8, the main research area is hydroxy lipid compound analysis geochem sample GC MS; butyldimethylsilyl etherification hydroxy lipid compound analysis GC MS.
To improve GC/MS anal. of hydroxy compounds from various sources, such as alkanols, sterols, diols, keto-ols and hydroxy fatty acids (FAs) with complex compositions, the authors evaluated their column-chromatog. separation after silylation. N-tertiary-butyldimethylsilylimidazole (t-BDMS) was expected to be the most effective silylating reagent to make -OH groups more inert and hence to promote separation according to the chem. and structural differences in their individual alkyl groups. The t-BDMS etherification of hydroxy compounds remarkably improved their purification and separation by strongly constraining or enhancing the chromatog. different behavior possibly caused by chem. and structural differences in the alkyl groups. Thus, the complex mixtures of hydroxy compounds from lacustrine and marine sediments were clearly fractionated into each major compound group, i.e., alkanols, sterols, diols, hydroxy FAs and keto-ols. Also, the individual sterols, diols and hydroxy FAs were separated into four, two and five specific sub-groups, resp. It is worth noting that, by using only one column, this anal. improvement was achieved with excellent reproducibility. Such fine fractionations resulted in a substantial decrease in the complexity of the gas chromatograms of all major hydroxy compounds The improvement enabled the authors to simply and accurately identify and quantify major as well as trace homologs and isomers of various hydroxy compounds with a high level of sensitivity using GC/MS. Consequently, the authors found some series of hitherto unknown compounds to serve as information sources for organisms and environments. The chromatog. fractionation following t-BDMS etherification of lipids from various geochem. samples provides not only a greater understanding of their mol. distributions and stable carbon isotopic ratios, but also substantially upgrades lipid anal. efficiency as a whole.
Organic Geochemistry published new progress about Etherification. 13099-34-8 belongs to class alcohols-buliding-blocks, name is 17-Hydroxyheptadecanoic acid, and the molecular formula is C17H34O3, Application In Synthesis of 13099-34-8.
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