Lura, Ard’s team published research in International Journal of Pharmaceutics: X in 2020-12-31 | CAS: 64519-82-0

International Journal of Pharmaceutics: X published new progress about Compressibility. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, COA of Formula: C12H24O11.

Lura, Ard published the artcileTableting of mini-tablets in comparison with conventionally sized tablets: A comparison of tableting properties and tablet dimensions, COA of Formula: C12H24O11, the main research area is minitablet property tablet dimension; Compaction simulator; Direct compression; Functionalized excipients; Mini-tablets; Tablet properties; Tablets.

Mini-tablets are solid dosage forms with increasing interest for pharmaceutical industry due to clin. and biopharmaceutical benefits. But technol. aspects on mini-tableting are not fully investigated. Therefore, the impact of punch size and tableting pressure for industrially relevant excipients like microcrystalline cellulose, lactose, isomalt and Ludiflash are investigated using 8 and 11.28 mm punches for conventionally sized tablets and 1,2 and 3 mm punches for mini-tablets. For evaluation of the effect of tablet size on deformation behavior and mech. properties, compressibility, compactibility and tabletability plots are created and evaluated. Deformation behavior is analyzed by In-Die Heckel plot and modified Weibull function. Further, specific plastic energy (SPE) profiles are generated out of force-displacement plots. The effect of the adjustment of the aspect ratio towards 1 as in conventionally sized tablets on deformation behavior and tabletability is analyzed. The effect of tablet size on deformation behavior mainly showed lower yield pressures for conventionally sized tablets, whereas comparable SPEs were obtained with all tablet sizes. Furthermore, mini-tablets indicate better compactibility, as (depending on the excipient) higher tensile strengths were obtained at lower solid fractions. However, no superior tabletability properties are obtained for mini-tablets compared to conventionally sized tablets.

International Journal of Pharmaceutics: X published new progress about Compressibility. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, COA of Formula: C12H24O11.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts