Luhn, Oliver published the artcileDissolution profile of novel composite pellet cores based on different ratios of microcrystalline cellulose and isomalt, Category: alcohols-buliding-blocks, the main research area is dissolution composite pellet microcrystalline cellulose isomalt Eudragit.
There is a growing interest towards the application of inert cores as starting materials for pharmaceutical pellet manufacturing They serve as alternatives to develop and adapt a relatively simple manufacturing technol. compared with an extrusion/spheronization process. The major objective of this study was to investigate the effect of the compositions of core materials on the drug release profile. Pure microcrystalline cellulose (MCC), isomalt and different types of novel composite MCC-isomalt cores were layered with model drug (sodium diclofenac) and were coated with acrylic polymer. The effect of the osmolality in the gastrointestinal tract was simulated using glucose as osmotically active agent during in vitro dissolution tests. The results demonstrated the dependence of drug dissolution profile on the ratio of MCC and isomalt in the core and the influence of osmotic properties of the dissolution medium. Isomalt used in the composite core was able to decrease the vulnerability of the dissolution kinetics to the changes in the osmotic environment. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci.
Journal of Pharmaceutical Sciences published new progress about Digestive tract. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Category: alcohols-buliding-blocks.
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