Huynh, Kenny W. published the artcileLactate inhibits naked mole-rat cardiac mitochondrial respiration, Name: (S)-2-hydroxysuccinic acid, the main research area is lactate mitochondrial respiration heart; Electron transport system; Hypoxia; Lactate dehydrogenase; Oxidative phosphorylation.
In aerobic conditions, the proton-motive force drives oxidative phosphorylation (OXPHOS) and the conversion of ADP to ATP. In hypoxic environments, OXPHOS is impaired, resulting in energy shortfalls and the accumulation of protons and lactate. This results in cellular acidification, which may impact the activity and/or integrity of mitochondrial enzymes and in turn neg. impact mitochondrial respiration and thus aerobic ATP production Naked mole-rats (NMRs) are among the most hypoxia-tolerant mammals and putatively experience intermittent hypoxia in their underground burrows. However, if and how NMR cardiac mitochondria are impacted by lactate accumulation in hypoxia is unknown. Author predicted that lactate alters mitochondrial respiration in NMR cardiac muscle. To test this, author used high-resolution respirometry to measure mitochondrial respiration in permeabilized cardiac muscle fibers from NMRs exposed to 4 h of in vivo normoxia (21% O2) or hypoxia (7% O2). Author found that: (1) cardiac mitochondria cannot directly oxidize lactate, but surprisingly, (2) lactate inhibits mitochondrial respiration, and (3) decreases complex IV maximum respiratory capacity. Finally, (4) in vivo hypoxic exposure decreases the magnitude of lactate-mediated inhibition of mitochondrial respiration. Taken together, author results suggest that lactate may retard electron transport system function in NMR cardiac mitochondria, particularly in normoxia, and that NMR hearts may be primed for anaerobic metabolism
Journal of Comparative Physiology, B: Biochemical, Systems, and Environmental Physiology published new progress about Acidification. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Name: (S)-2-hydroxysuccinic acid.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts