Fisher, Gordon published the artcileSex and race contribute to variation in mitochondrial function and insulin sensitivity, Related Products of alcohols-buliding-blocks, the main research area is skeletal muscle myofiber insulin hydrogen peroxide; insulin sensitivity; mitochondrial function; race; reactive oxygen species; sex.
Insulin sensitivity is lower in African American (AA) vs. Caucasian American (CA). We tested the hypothesis that lower insulin sensitivity in AA could be explained by mitochondrial respiratory rates, coupling efficiency, myofiber composition, or H2O2 emission. A secondary aim was to determine whether sex affected the results. AA and CA men and women, 19-45 years, BMI 17-43 kg m2, were assessed for insulin sensitivity (SIClamp) using a euglycemic clamp at 120 mU/m2/min, muscle mitochondrial function using high-resolution respirometry, H2O2 emission using amplex red, and % myofiber composition SIClamp was greater in CA (p < 0.01) and women (p < 0.01). Proportion of type I myofibers was lower in AA (p < 0.01). Mitochondrial respiratory rates, coupling efficiency, and H2O2 production did not differ with race. Mitochondrial function was pos. associated with insulin sensitivity in women but not men. Statistical adjustment for mitochondrial function, H2O2 production, or fiber composition did not eliminate the race difference in SIClamp. Neither mitochondrial respiratory rates, coupling efficiency, myofiber composition, nor mitochondrial reactive oxygen species production explained lower SIClamp in AA compared to CA. The source of lower insulin sensitivity in AA may be due to other aspects of skeletal muscle that have yet to be identified. Physiological Reports published new progress about Body mass index. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Related Products of alcohols-buliding-blocks.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts