Timko, Lukas published the artcileSynthesis, physicochemical properties and biological activities of novel alkylphosphocholines with foscarnet moiety, Name: 2-Morpholinoethanol, the publication is Bioorganic Chemistry (2020), 104224, database is CAplus and MEDLINE.
A series of alkylphosphocholines with foscarnet moiety was synthesized. The structure of these zwitterionic amphiphiles was modified in both polar and non-polar parts of surfactant mol. Investigations of physicochem. properties are represented by the determination of critical micelle concentration, the surface tension value at the cmc and the surface area per surfactant head group utilizing surface tension measurements. Hydrodynamic diameter of surfactant micelles was determined using the dynamic light scattering technique. Alkylphosphocholines exhibit significant cytotoxic, anticandidal (Candida albicans) and antiamoebal (Acanthamoeba spp. T4 genotype) activity. The relationship between the structure, physicochem. properties and biol. activity of the tested compounds revealed that lipophilicity has a significant influence on biol. activity of the investigated surfactants. More lipophilic alkylphosphocholines with octadecyl chains show cytotoxic activity against cancer cells which is higher than that of the compounds with shorter alkyl chains. The opposite situation was observed in case of anticandidal and antiamoebal activity of these surfactants. The most active compounds were found to have pentadecyl chains. The foscarnet analog of miltefosine C15-PFA-C showed the highest anticandidal activity. The min. value of anticandidal activity of this compound is 1,4μM thus representing the highest anticandidal activity found within the group of alkylphosphocholines.
Bioorganic Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C22H38O2, Name: 2-Morpholinoethanol.
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