Suzuki, Yumena published the artcileExploring novel cocrystalline forms of oxyresveratrol to enhance aqueous solubility and permeability across a cell monolayer, COA of Formula: C11H8O3, the publication is Biological & Pharmaceutical Bulletin (2019), 42(6), 1004-1012, database is CAplus and MEDLINE.
Oxyresveratrol (ORV) is a naturally extracted compound with many pharmacol. activities. However, information about the crystalline form is not known when considering the development of a form for oral dosage. Cocrystal engineering offers drug mol. understanding and drug solubility improvements. Thus, we attempted cocrystn. of ORV using 10 carboxylic acids as a coformer at a 1:1 M ratio. Each combination was processed with liquid-assisted grinding, solvent evaporation and a slurry method, then characterized by powder X-ray powder diffraction (PXRD), conventional and low-frequency Raman spectroscopy and thermal anal. The solubility, dissolution and permeation studies across Caco-2 cell monolayers were conducted to evaluate the ORV samples. A screening study revealed that an ORV and citric acid (CTA) cocrystal formed by Et acetate-assisted grinding had characteristic PXRD peaks (14.0 and 16.5°) compared to those of ORV dihydrate used as a starting material. Low-frequency Raman measurements, with peaks at 100 cm-1, distinguished potential cocrystals among three processing methods while conventional Raman could not. An endothermic melt (142.2°C) confirmed the formation of the novel crystalline complex. The solubility of the cocrystal in the dissolution media of pH 1.2 and 6.8 was approx. 1000μg/mL, a 1.3-fold increase compared to ORV alone. In vitro cytotoxicity studies showed that the cocrystal and phys. blend were not toxic at concentrations of 25 and 12.5μM ORV, resp. The ORV-CTA cocrystal enhanced the cellular transport of ORV across Caco-2 monolayers. Therefore, cocrystn. could be used to improve aqueous solubility and permeability, leading to better oral bioavailability of ORV.
Biological & Pharmaceutical Bulletin published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C7H13BrSi, COA of Formula: C11H8O3.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts