Subramanian, R. published the artcileTissue distribution of indium-111-labeled human monoclonal antibody (16.88) in nude mice bearing tumor xenografts: effect of diester linkage, COA of Formula: C18H20N2O12, the publication is Antibody, Immunoconjugates, and Radiopharmaceuticals (1990), 3(2), 127-36, database is CAplus.
A human IgM anticolorectal monoclonal antibody 16.88 was coupled to DTPA using a diester linkage in an attempt to reduce retention of radioactivity in normal organs of animals receiving the 111In-labeled conjugate. For comparison, a 16.88-DTPA conjugate with a peptide linkage was also prepared The diester and peptide conjugates contained 3.4 and 4.3 mols. of DTPA per 16.88, resp., and their immunoreactivity was >90% as assessed by a direct-cell binding assay. Biodistribution studies in nude mice bearing THO human colon tumor xenografts indicated that diester linked conjugate was retained to a lesser extent in tumor and normal organs such as liver and kidney as compared to the peptide conjugate. The clearance of the diester conjugate from blood, however, was much faster than that of the peptide conjugate. This resulted in 2-fold higher tumor-to-serum ratio for the diester conjugate than for the peptide conjugate.
Antibody, Immunoconjugates, and Radiopharmaceuticals published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C19H21N3O3S, COA of Formula: C18H20N2O12.
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