Shaaban, Heba published the artcileSimultaneous determination of bisphenol A and its analogues in foodstuff using UPLC-MS/MS and assessment of their health risk in adult population, HPLC of Formula: 80-09-1, the publication is Journal of Food Composition and Analysis (2022), 104549, database is CAplus.
Replacing bisphenol A with its analogs may represent a risk to human health because of their potential synergic effects. In this study, a fast, sensitive and reliable UPLC-MS/MS method for the identification and quantification of bisphenol A, bisphenol F, bisphenol S, D8 and pergafast in foodstuff was developed and validated. Sample preparation and clean up were carried out using ultrasonic extraction followed by solid-phase extraction on Oasis HLB cartridges. The developed method was successfully applied for simultaneous determination of the target analytes in 140 food samples from various categories (including: vegetables, dairy products, seafood products, condiments, beverages, oils & fats and others). The recovery ranged from 80.3% to 103.8% with relative standard deviations not higher than 11.5%. Limits of detection were within the range of 0.003-0.015μg kg-1 under the optimized conditions. Bisphenol A was found in the majority of food samples (83%) with the highest concentration of 110μg kg-1. Canned food contained higher concentrations of total bisphenols (23.8μg kg-1) compared to food samples packed in plastic containers (7.68μg kg-1), paper (3.53μg kg-1) or glass (1.14μg kg-1). The estimated daily intake for the detected bisphenols was also calculated (286.7 and 307.8 ng kg-1 BW day-1) for male and female adults, resp. The dietary exposure to total bisphenols through foodstuffs investigated in this study were found to be higher than the recently updated tolerable daily intake value of BPA (0.04 ng kg-1 BW day-1). Also, the calculated hazard index was found to be higher than 1, indicating that the exposure to the detected bisphenols is more likely to cause risk to consumers through the dietary intake. To the best of our knowledge, this is the first report estimating the health risk associated with dietary exposure to bisphenol A and its analogs in Saudi Arabia.
Journal of Food Composition and Analysis published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C7H5Cl2NO, HPLC of Formula: 80-09-1.
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