Rastogi, Supriya published the artcileAllergic contact dermatitis to personal care products and topical medications in adults with atopic dermatitis, COA of Formula: C11H24O3, the publication is Journal of the American Academy of Dermatology (2018), 79(6), 1028-1033.e6, database is CAplus and MEDLINE.
Atopic dermatitis (AD) is associated with skin-barrier disruption, immune dysregulation, and application of emollients and topical medications that might predispose a person toward developing allergic contact dermatitis. To determine the predictors of allergic contact dermatitis and relevant allergens in AD. A retrospective chart review was performed for 502 adults (age ≥18 years) who were patch tested to an expanded allergen series during 2014-2017. Overall, 108 (21.5%) had current AD and 109 (21.7%) had past AD. Patients with and without current AD had similar proportions of any pos. (+, ++, or +++ 80 [74.1%] vs 254 [64.5%], resp., chi-squared P = .06); strong-pos. (++ and +++ 34 [31.5%] vs 102 [25.9%], resp., P = .25); and irritant (56 [51.9%] vs 188 [47.7%], resp., P = .45) patch-test reactions. AD patients had significantly higher rates of pos. reactions to ingredients in their personal care products and topical medications, including fragrance mix II (P = .04), lanolin (P = .03), bacitracin (P = .04), cinnamal (P = .02), budesonide (P = .01), tixocortol (P = .02), and chlorhexidine (P = .001); relevance was established in >90% of these reactions. Polysensitization occurred more commonly in patients with AD than without (35 [32.4%] vs 75 [19.0%]; P = .01). Study was performed at a single center. AD patients had more pos. patch-test reactions to ingredients in their personal care products, topical steroids, and antibiotics.
Journal of the American Academy of Dermatology published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, COA of Formula: C11H24O3.
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