Pan, Bendu published the artcileIridium-catalyzed intramolecular asymmetric allylic etherification of salicylic acid derivatives with chiral-bridged biphenyl phosphoramidite ligands, Related Products of alcohols-buliding-blocks, the publication is Organic Chemistry Frontiers (2021), 8(16), 4514-4519, database is CAplus.
Iridium-catalyzed intramol. asym. allylic etherification of salicylic acid derivatives was successfully realized for the first time. By using chiral-bridged biphenyl phosphoramidite ligand, a class of novel chiral 1,4-benzoxazepinones I [R1 = H, 6-Me, 9-MeO, 8-F; R2 = Bn, 4-MeOC6H4CH2] was prepared conveniently with good to excellent yields (up to 99%) and high enantioselectivities (up to 99% ee). The effect of different substituents on the enantioselectivity was also discussed. Compared with BINOL or biphenol-derived counterparts, catalysis with ligand had obvious advantages in terms of catalytic activity and enantioselectivity. Mild conditions and a wide substrate scope demonstrated the practicability of this method. It was also found that the configuration of the product was directly related to the configuration of the alkene substrate and the E-substrate is more suitable for this reaction to obtain better enantioselectivity.
Organic Chemistry Frontiers published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Related Products of alcohols-buliding-blocks.
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