Odoardi, Sara published the artcileMetabolism study and toxicological determination of mephtetramine in biological samples by liquid chromatography coupled with high-resolution mass spectrometry, Recommanded Product: 1-Hydroxy-2-naphthoic acid, the publication is Drug Testing and Analysis (2021), 13(8), 1516-1526, database is CAplus and MEDLINE.
The emerging market of new psychoactive substances (NPSs) is a global-scale phenomenon, and their identification in biol. samples is challenging because of the lack of information about their metabolism and pharmacokinetic. In this study, we performed in silico metabolic pathway prediction and in vivo metabolism experiments, in order to identify the main metabolites of mephtetramine (MTTA), an NPS found in seizures since 2013. MetaSite software was used for in silico metabolism predictions and subsequently the presence of metabolites in the blood, urine, and hair of mice after MTTA administration was verified. The biol. samples were analyzed by liquid chromatog. coupled with high-resolution mass spectrometry (LC-HRMS) using a benchtop Orbitrap instrument. This confirmed the concordance between software prediction and exptl. results in biol. samples. The metabolites were identified by their accurate masses and fragmentation patterns. LC-HRMS anal. identified the dehydrogenated and demethylated-dehydrogenated metabolites, together with unmodified MTTA in the blood samples. Besides unmodified MTTA, 10 main metabolites were detected in urine. In hair samples, only demethyl MTTA was detected along with MTTA. The combination of Metasite prediction and in vivo experiment was a powerful tool for studying MTTA metabolism This approach enabled the development of the anal. method for the detection of MTTA and its main metabolites in biol. samples. The development of anal. methods for the identification of new drugs and their main metabolites is extremely useful for the detection of NPS in biol. specimens. Indeed, high throughput methods are precious to uncover the actual extent of use of NPS and their toxicity.
Drug Testing and Analysis published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Recommanded Product: 1-Hydroxy-2-naphthoic acid.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
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