Kondo, Hiroki published the artcileσ-Bond Hydroboration of Cyclopropanes, Application of 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, the publication is Journal of the American Chemical Society (2020), 142(25), 11306-11313, database is CAplus and MEDLINE.
Hydroboration of alkenes is a classical reaction in organic synthesis, in which alkenes react with boranes to give alkylboranes, with subsequent oxidation resulting in alcs. The double bond (π-bond) of alkenes can be readily reacted with boranes owing to its high reactivity. However, the single bond (σ-bond) of alkanes has never been reacted. To pursue the development of σ-bond cleavage, the authors selected cyclopropanes as model substrates since they present a relatively weak σ-bond. Herein, the authors describe an Ir-catalyzed hydroboration of cyclopropanes, resulting in β-Me alkylboronates. These unusually branched boronates can be derivatized by oxidation or cross-coupling chem., accessing designer products that are desired by practitioners of natural product synthesis and medicinal chem. Also, mechanistic studies and theor. studies revealed the enabling role of the catalyst.
Journal of the American Chemical Society published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Application of 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol.
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