Kikugawa, Yasuo’s team published research in Journal of Organic Chemistry in 68 | CAS: 2240-88-2

Journal of Organic Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Safety of 3,3,3-Trifluoropropan-1-ol.

Kikugawa, Yasuo published the artcileIntramolecular Cyclization with Nitrenium Ions Generated by Treatment of N-Acylaminophthalimides with Hypervalent Iodine Compounds: Formation of Lactams and Spiro-Fused Lactams, Safety of 3,3,3-Trifluoropropan-1-ol, the publication is Journal of Organic Chemistry (2003), 68(17), 6739-6744, database is CAplus and MEDLINE.

In hexafluoroisopropyl alc., N-phthalimido-N-acylnitrenium ions, generated from N-acylamino phthalimides I [X = O, CH2, (CH2)2, (CH2)3, OCH2, etc.; R = H, 4-Me, 2-Cl, 4-MeO, 2,4-F2, etc.] by treatment with hypervalent iodine compounds, phenyliodine bis(trifluoroacetate) (PIFA) or its 4-chloro-substituted derivative, underwent intramol. electrophilic substitution reactions to afford N-phthalimido azaheterocycles II in high yields. Treatment of I [X = OCH2, (CH2)2, (CH2)3] with PIFA or [hydroxy(tosyloxy)iodo]benzene (HTIB) in 2,2,2-trifluoroethanol gave spirodienones, e.g. III, as a result of ipso attack of the intermediate nitrenium ion.

Journal of Organic Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Safety of 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts